Erythema Multiforme

Overview

Erythema multiforme is an acute, immune-mediated skin condition characterized by distinctive target-shaped (bulls-eye) lesions. It is most commonly triggered by herpes simplex virus (HSV) infection, though medications and other infections can also be causes. It is usually self-limiting but can recur.

Key Symptoms

Distinctive target or bulls-eye shaped lesions with concentric rings
Lesions appear symmetrically on the body
Mild itching or burning at lesion sites
May involve the lips and oral mucosa with painful erosions
Lesions evolve over several days, with new crops appearing
Low-grade fever and malaise may accompany the rash

Affected Areas

Hands and palms, Feet and soles, Forearms, Face, Oral mucosa

Care Instructions

See a dermatologist for diagnosis and to identify the trigger.
Treat underlying herpes simplex infection if identified as the cause.
Symptomatic relief with antihistamines for itching and topical corticosteroids.
Use a gentle mouthwash or topical anesthetic for oral lesions.
Prophylactic antiviral therapy may be prescribed for recurrent HSV-related episodes.
Discontinue any suspected causative medication under medical guidance.

Medical Disclaimer: This information is for educational purposes only and does not replace professional medical advice. Always consult a qualified dermatologist for diagnosis and treatment.

Prevalence: Relatively uncommon; peak incidence in young adults aged 20–40