Bullous Pemphigoid

Bullous Pemphigoid

Overview

Bullous pemphigoid is a chronic autoimmune blistering disease that causes large, tense, fluid-filled blisters on the skin. It results from antibodies attacking the basement membrane zone between the epidermis and dermis. It primarily affects older adults and can cause significant discomfort and secondary infections if untreated.

Key Symptoms

• Large, tense, fluid-filled blisters on the skin
• Blisters may arise on normal or reddened skin
• Intense itching, often preceding blister formation
• Blisters most common on trunk, arms, and legs
• Blisters do not rupture easily due to thick roof
• May have urticarial (hive-like) patches before blisters appear

Affected Areas

Trunk, Arms, Legs, Groin, Axillae

Care Instructions

1. See a dermatologist promptly for diagnosis and treatment.
2. Treatment typically involves topical or systemic corticosteroids.
3. Keep blisters intact when possible to prevent infection.
4. Gently cleanse ruptured blisters and apply prescribed topical treatments.
5. Immunosuppressive medications may be needed for severe or resistant cases.
6. Attend regular follow-up visits to monitor disease activity and medication side effects.

Medical Disclaimer: This information is for educational purposes only and does not replace professional medical advice. Always consult a qualified dermatologist for diagnosis and treatment.

Prevalence: Relatively uncommon; primarily affects adults over age 60, with incidence of approximately 6–13 per million per year